Immune/microbial interface perturbation in human IgA deficiency

T-LYMPHOCYTES IN IgA DEFICIENCY

Common variable immunodeficiency (CVID) and IgA deficiency (IgAD) are primary humoral immune deficiencies with a similar genetic background, but clinical and laboratory manifestation of CVID is much more severe than that of IgAD. The aim of this study was to determine whether some abnormalities in T-lymphocyte subsets or function observed in CVID are also present in IgAD patients. T-lymphocyte ...

Syndrome with IgA Deficiency

Autosomal deletion syndromes are of great interest since measurable loss of genetic material could lead to the mapping of the human autosomes. Short arm deletions and long arm deletions of chromosome 18 have been described in association with phenotypic changes (Grouchy et al., 1963, 1964) and reviewed recently by Wolf et al. (1967) and Reinwein, Ritter, and Wolf (1967). Since a ring chromosome...

Spondyloarthropathies and IgA deficiency.

IgA deficiency and neutropenia

That the anuria was apparently painless yet due to bilateral obstruction of the ureters by calculi is noteworthy. Herring,4 in a study of 10 000 urinary calculi, found only 89 to contain cystine, of which about 700,, were composed of pure cystine, as in our case. Thus urinary tract calculi may be due to cystinuria even in a young child. Cystinuria5 is a recessive or incompletely recessive genet...

IgA nephropathy with complement deficiency.

We treated a female patient suffering from immunoglobulin A (IgA) nephropathy and congenital deficiency of the ninth component of the complement system (C9). She was admitted with hematuria and proteinuria, and the C9 deficiency was diagnosed based on the low hemolytic activity of 50 % of the hemolytic unit of the complements (CH50) and the normal C3 level in the plasma. Renal biopsy revealed m...